Neuroimmunology Program - IDIBAPS

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Dr. Josep Dalmau

Pathogenesis of immune-mediated neurological disorders

Current Positions

  • ICREA Senior Investigator, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, Spain
  • Adjunct Professor of Neurology, University of Pennsylvania
  • Director, Laboratory for the study of the pathogenesis of immune-mediated neuronal disorders, Institut D’Investigacions Biomédiques August Pi I Sunyer, Hospital Clinic, University of Barcelona, Spain
  • Member of the editorial boards of: Neurology, Neurología, UpTo Date in Neurology
  • Member of the American Academy of Neurology, American Neurologic Association, American Society of Clinical Oncology, Society for Neuro-oncology, Spanish Society of Neurology, Catalan Society of Neurology,

Academic Qualifications

  • Degree in Medicine and Surgery from the Autonomous University of Barcelona, 1976
  • Doctorate of Medicine and Surgery from the Autonomous University of Barcelona, 1993
  • Fellowship in Neuro-oncology at the Memorial Sloan-Kettering Cancer Center, New York, USA, 1988-92

Areas of Research

  • Study of autoimmune encephalitis and other immune-mediated neurologic disorders
  • Diagnosis and treatment of neurologic problems in patients with cancer
  • Role of autoimmunity in memory and cognition

Honors and Awards

  • Jacoby Award, American Neurological Association for meritorious experimental work
  • Best manuscript prize, Annals of Neurology
  • Lady Barbara Colyton Prize for Autoimmune Research, University of Pennsylvania Stanley Gore lecture, University of Chicago Award for Excellence in Teaching, University of Pennsylvania
  • Distinguished Lectureship in Neurosciences, University of Toronto
  • Editors of Brain Lecture Association of British Neurologists
  • John Tibbles Lecture, Canadian Association of Child Neurology
  • TEVA Neuroscience Parisi Lecture American Association of Neuropathologists
  • Frontiers in Clinical Neuroscience Lecture, American Academy of Neurology
  • Catalan Society of Neurology, Young Investigator Award

Grants for Medical Research

  • National Institutes of Health (NIH), USA
  • National Cancer Institute (NCI), USA
  • Fund for Health Research (FIS), Spain
  • TV3 Marathon Foundation, TV3, Catalonia, Spain
  • McKnight Foundation, USA
  • Charles A. Dana Foundation, USA

Recent Selected Publications

  • Armangue T, Moris G, Cantarin-Extremera V, Conde C, Rostasy K, Erro E, Portilla-Cuenca JC, Turon E, Málaga I, Cabello Muñoz B, Torres-Torres C, Llufriu S, López-Solana G, González G, Casado Naranjo I, Rosenfeld M, Graus F, Dalmau J. Autoimmune post-herpes simplex encephalitis of adults and teenagers. Neurology, in press.
  • Höftberger R, van Sonderen A, Leypoldt F, Geschwind M, Gelfand J, Paredes M, Houghton D, Sabater L, Saiz A, Titulaer MJ, Graus F, Dalmau J. Encephalitis and AMPA receptor antibodies: novel findings in a case series of 22 patients. Neurology. 2015;84:2403-2412.
  • Planagumà J, Leypoldt F, Mannara F,  Gutiérrez-Cuesta J, Martín-García E, Aguilar E, Titulaer MJ, Petit-Pedrol M, Jain A, Balice-Gordon R, Lakadamyali M, Graus F, Maldonado R, Dalmau J. Human N-Methyl-D-aspartate receptor antibodies alter memory and behavior in mice. Brain 2015; 138:94-109
  • Titulaer MJ, Höftberger R, Iizuka T, Leypoldt F, McCracken L, Cellucci T, Benson LA, Shu H, Irioka T, Hirano M, Singh G, Cobo Calvo A, Kaida K, Morales PM, Wirtz PW, Yamamoto T, Reindl M, Rosenfeld MR, Graus F, Saiz A, Dalmau J. Overlapping demyelinating syndromes and anti-NMDA receptor encephalitis. Ann Neurol 2014;75:411-428.
  • Petit-Pedrol M, Armangue T, Peng X, Bataller L, Cellucci T, Davis R, McCracken L, Martinez-Hernandez E, Mason wP, Kruer MC, Ritacco DG, Grisold W, Meaney BF, Alcalá C, Sillevis-Smitt P, Titulaer MJ, Balice-Gordon R, Graus F, Dalmau J. Encephalitis with refractory seizures, status epilepticus, and antibodies to the GABAA receptor: a case series characterization of the antigen, and analysis of the effects of antibodies. Lancet Neurol 2014;13:276-286.
  • Gresa-Arribas N, Titulaer MJ, Torrents A, Aguilar E, McCracken L, Leypoldt F, Gleichman AJ, Balice-Gordon R, Rosenfeld MR, Lynch D, Graus F, Dalmau J. Antibody titres at diagnosis and during follow-up of anti-NMDA receptor encephalitis: a retrospective study. Lancet Neurol 2014;13:167-177.
  • Titulaer MJ, McCracken L, Gabilondo I, Armangue T, Glaser C, Iizuka T, Honig LS, Benseler S, Kawachi I, Martinez-Hernandez E, Aguilar E, Gresa-Arribas N, Ryan-Florance N, Torrents A, Saiz A, Rosenfeld MR, Balice-Gordon R, Graus F, Dalmau J. Treatment and prognostic factors for long-term outcome in patients with anti-N-Methyl-D-Aspartate (NMDA) receptor encephalitis: a cohort study. Lancet Neurol 2013;12:157-165.  

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