Neuroimmunology Program - IDIBAPS

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Dr. Francesc Graus

Immunoathogenesis of brain paraneoplastic syndromes

Current Positions

  • Chief of the Department of Neurology of Hospital Clínic, Barcelona
  • Professor of Medicine of the University of Barcelona
  • Senior Consultant at Hospital Clínic, Barcelona
  • Director, Laboratory Clinical and Experimental Neuroimmunology, Institut D’Investigacions Biomédiques August Pi I Sunyer, Hospital Clinic, University of Barcelona, Spain
  • Past-Director of the Brain and Nervous System Tissue Bank of the Hospital Clinic and University of Barcelona
  • Member and Past President of the Executive Board of the European Association of Neuro-oncology
  • Member of the editorial boards of: European Journal of Neurology, Lancet Neurology, Medicina Clínica, Neurologia
  • Member of the American Academy of Neurology, American Neurologic Association, European Neurology Society, Spanish Society of Neurology, Catalan Society of Neurology

Academic Qualifications

  • Degree in Medicine and Surgery from the Autonomous University of Barcelona, 1976
  • Doctorate of Medicine and Surgery from the Autonomous University of Barcelona, 1982
  • Fellowship in Neuro-oncology at the Memorial Sloan-Kettering Cancer Center, New York, USA, 1982-85

Areas of Research

  • Study of immune mechanisms and develop treatments for paraneoplastic neurologic syndromes
  • Development of new therapies for brain cancer
  • Diagnosis and treatment of neurologic problems in patients with cancer
  • Autoimmune disorders. IgLON5 associated encephalopathy

Honors and Awards

  • Honorary Doctorate, Université Caude Bernard Lyon, France

Grants for Medical Research

  • Fund for Health Research (FIS), Spain
  • TV3 Marathon Foundation, TV3, Catalonia, Spain
  • Spanish Ministry of Science and Technology
  • Catalan Society of Neurology
  • European Commission

Recent Selected Publications

  • Arino H, Hoftberger R, Gresa-Arribas N, Martinez-Hernandez E, Armangue T, Kruer MC, et al. Paraneoplastic Neurological Syndromes and Glutamic Acid Decarboxylase Antibodies. JAMA Neurol. 2015 Aug 1;72(8):874-81.
  • Boronat A, Gelfand JM, Gresa-Arribas N, Jeong HY, Walsh M, Roberts K, et al. Encephalitis and antibodies to dipeptidyl-peptidase-like protein-6, a subunit of Kv4.2 potassium channels. Ann Neurol. 2013 Jan;73(1):120-8.
  • Gaig C, Iranzo A, Santamari J, Dalmau J, Graus F. Sleep disorder associated with antibodies to IgLON5: parasomnia or agrypnia?-Authors' reply. Lancet Neurol. 2014 Sep;13(9):864-5. doi: S1474-4422(14)70157-7
  • Gresa-Arribas N, Arino H, Martinez-Hernandez E, Petit-Pedrol M, Sabater L, Saiz A, et al. Antibodies to inhibitory synaptic proteins in neurological syndromes associated with glutamic acid decarboxylase autoimmunity. PLoS One. 2015;10(3):e0121364.
  • Hoftberger R, Titulaer MJ, Sabater L, Dome B, Rozsas A, Hegedus B, et al. Encephalitis and GABAB receptor antibodies: novel findings in a new case series of 20 patients. Neurology. 2013 Oct 22;81(17):1500-6.
  • Martin-Garcia E, Mannara F, Gutierrez-Cuesta J, Sabater L, Dalmau J, Maldonado R, et al. Intrathecal injection of P/Q type voltage-gated calcium channel antibodies from paraneoplastic cerebellar degeneration cause ataxia in mice. J Neuroimmunol. 2013 Aug 15;261(1-2):53-9.
  • Sabater L, Gaig C, Gelpi E, Bataller L, Lewerenz J, Torres-Vega E, et al. A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing disorder associated with antibodies to IgLON5: a case series, characterisation of the antigen, and post-mortem study. Lancet Neurol. 2014 Jun;13(6):575-86.

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