Brain architecture or connectivity is complex and defines the basis of cognitive processing. Recent studies have revealed new insights about its organization by the combination of structural magnetic resonance imaging (MRI) such as tractography (using for e.g. Diffusion Spectrum Imaging, DSI) and functional MRI (fMRI) using resting-state.
Moreover, MRI analysis of MS by DSI and fMRI can provide new insights about MS pathogenesis and development of new biomarkers of the disease. MS is a common neurological disease that attacks the young population in the northern countries, women preferentially afflicted.
We aim to analyze structural and functional connectivity networks in patients with MS in order to improve our understanding about the organization of brain networks using MS lesions as a perturbation to the networks. In addition, we aim to use the analysis of brain connectivity as biomarkers of the disease.